Photo: Gleb Schelkunov / Kommersant
A group of scientists at MSU have developed a new method of treatment of consequences of myocardial infarction using gene therapy. A study published in the journal PLOS One, reported in a press release.
Experts offer to deliver genes HGF and VEGF165 in the affected area of the heart is to encode proteins, growth of cells, the inner walls of blood vessels and protect heart cells from death during ischemia. Initially, scientists assumed that during the experiment, the simultaneous activation of the gene for the growth factor of hepatocytes (liver cells) HGF, which has multiple (pleiotropic) effects, with the gene of the growth factor vascular endothelial VEGF165 will lead to the growth of blood vessels.
“We found that well-known anti-inflammatory effect of HGF resulted in a decrease in the efficiency of arteriogenesis, who had a good run with VEGF165, has inflammatory effects in the tissue, — said the candidate of medical Sciences Pavel Makarevich, head of the laboratory of gene-cell therapy of the Institute for regenerative medicine of Moscow state University. — In addition, we found that we have developed gene therapy activates the stem cells of the heart — the reserve which the body can use for recovery of the myocardium after injury”.
Scientists believe that their study can be used to treat patients after myocardial infarction.
Video, photo All from Russia.