Photo: Lucy Nicholson / Reuters
Scientists from Yale cancer research center in the US have discovered a new mechanism of occurrence of rare hereditary forms of cancer. It turned out that malignant tumors are formed due to violations of the processes of recovery of damaged DNA. About it reported in a press release on MedicalXpress.
The researchers studied several syndromes that can lead to cancer. The first is called hereditary Lam and pochernkletocny carcinoma (HLRCC) and the second is associated with succinate-dehydrogenase hereditary paraganglioma and pheochromocytoma. Both conditions increase the risk of tumours that can be benign or malignant. Tumors are treated surgically, however, with the appearance of metastases surgical intervention becomes ineffective.
In both diseases, cells produce an abnormal amount of metabolites participating in the biochemical processes of conversion of carbohydrates, fats and proteins into energy. This is due to defects in the genes that encode the enzymes necessary for transformation of these metabolites in other compounds. However, scientists have found that high levels of metabolites, in turn, may interfere with homologous recombination, which is used by cells to restore DNA.
According to scientists, the tumour can be treated with drugs called the inhibitors of poly(ADP-ribose) polymerases (PARP). PARP inhibitors are designed to kill cancer cells that have lost the ability to repair DNA through homologous recombination. These preparations “seek” the ability of cells to repair damaged DNA, thereby killing them.
Video, photo All from Russia.