The particularly dangerous form of cancer

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Photo: Jonathan Ernst / Reuters

An international group of researchers headed by scientists at Imperial College London have found that a molecule called Yin Yang1, promotes the growth and of the incurability of breast cancer. About it reported in a press release on MedicalXpress.

Protein Yin Yang1 (YY1) is a transcription factor that is involved in the regulation of transcription of certain genes. To determine its role in cancer development, the researchers analyzed gene activity in the tumor tissues from 37 patients with estrogen-receptor positive (ER-positive) breast cancer. This type of the disease accounts for 70 percent of all cases of breast cancer and treated with hormonal therapy.

In particular, scientists have found what enhancers are involved in cancer cells. Enhancers — stretches of DNA that bind transcription factors, increase gene activity, which may be located either nearby or even on another chromosome.

It turned out that the enhancers involved in the regulation of genes Yin Yang 1 and SLC9A3R1 are activated at a certain stage of tumor development, helping them to grow and become resistant to treatment. While SLC9A3R1, which makes a decisive contribution to the growth of malignant cells is regulated by Yin Yang 1.

Video, photo All from Russia.

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