Photo: Joan E. Nichols, Jean A. Niles, And Joaquin Cortiella
Scientists at the University of Texas at Galveston first raised the light and successfully transplanted them into pigs, which survived for several weeks after surgery. This publication reports Science News.
According to the researchers, the tissue of transplanted lungs developed healthy blood vessels, causing the bodies were able to settle down. In previous experiments lungs transplanted into rodents, continued to function for several hours. In addition, organs grown from own cells of the recipient, which reduces the risk of rejection due to the immune system.
In the experiment, scientists using a mixture of detergent and sugar separated the cells from the lungs of pigs donor, the result of which was a 3D frame of intercellular proteins. In it, scientists began to grow a culture of cells isolated from animals-recipients. Lungs were grown for 30 days in the tank of a bioreactor filled with nutrient solutions. Ready organs were transplanted to four pigs instead of the left lung.
Animals were euthanized after 10 hours, two weeks, a month and two months after surgery. They an autopsy was performed to assess how well the engrafted organs. Throughout the experience of the pigs did not receive immunosuppressants, but scientists did not reveal signs of rejection of the transplanted organ in any of the cases. At the same time, the researchers note that the artificial organs were not functional because they did not connect with the pulmonary arteries.
Scientists hope that in the future they will be able to improve method and get proper authorities. In the case of transplantation of the artificial light to create a framework can be used in 3D printing.
Video, photo All from Russia.