Image: Y. Onodera, et al., Nature Communications / medicalxpress.com
Scientists at the University of Hokkaido (Japan) have identified a mechanism that promotes the growth of resistant to radiation therapy of cancerous tumors. About it reported in a press release on MedicalXpress.
They found that in cancer cells there is a metabolic pathway involved in the movement of mitochondria to the outer membrane, which increases the ability of cancer to infiltrate healthy tissue.
It is known that the cell surface protein is an integrin, which contributes to their interaction with the extracellular matrix. The signals, which come from integrins, communicating with the external side of the membrane with defined molecules that initiate processes such as the movement of organelles in the cytoplasm, attaching cells to other cells (adhesion), as well as differentiation and death.
The researchers showed that the accumulation of integrin leads to the formation of the adhesion complex on the cell surface, which in turn, via the signal path Arf6-AMP1-PRKD2, contributes to the accumulation of mitochondria in the cell periphery.
The blocking of the signals helped to prevent the movement of organelles from the center and reduce the invasiveness of cancer cells. In addition, mitochondria have a large amount of reactive oxygen species, leading to oxidative stress and death of malignant cells.
According to experts, the discovery will help to improve the effectiveness of radiation therapy, to which some types of malignant tumors acquire resistance.
Video, photo All from Russia.