Photo: Pavel Lisitsyn / RIA Novosti
Scientists from Stanford University explained why the blood transfused to young mice from old animals, causes premature aging of the brain. It turned out that under these conditions, activated by a specific protein, the suppression of which could slow down age-related changes in the Central nervous system in humans. Preprint of a study published in the repository bioRxiv.
In the study, biologists have studied what genes were active in the old cells of the blood-brain barrier that separates the circulatory system in the vertebrate brain from the nerve cells. In the experiment, we used young rodents, the skull of which is introduced the plasma from old animals. Scholars have analyzed the consequences of this procedure for the hippocampus region of the brain important for learning and memory formation are the most vulnerable to neurodegenerative diseases.
It turned out that the cells of the barrier begin to activate genes responsible for the synthesis of a specific protein called vascular cell adhesion molecule 1 (VCAM1). This protein inhibits the formation of new nerve cells in the hippocampus and contributes to inflammatory reactions of microglia — immune cells of the Central nervous system.
According to the researchers, blocking the actions of VCAM1 will allow to slow down the aging brain. It is shown that in genetically modified mice with the corresponding gene of the inactive blood, transfused from old animals had a strong effect. The antibodies inhibited the activity of protein, also stop neurodegeneration.
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