Photo: Ted S. Warren / AP
Scientists at the University of Michigan have discovered the mechanism whereby stem cells of the reproductive system remain eternally young, that is able to divide endlessly. Although it is found in fruit flies, one must have its counterpart. About it reported in a press release on MedicalXpress.
It is known that loss of the ribosomal DNA (rDNA), which encodes components for protein synthesis ribosomes, associated with the aging process in yeast. In rDNA is multiple copies of the same genes, because cells need lots of ribosomes. When copying of the genome, which occurs during cell division, mistakes happen, causing some genes fall out of the DNA.
However, in stem cells of reproductive organs in multicellular organisms such as fruit flies, ageing, associated with the rDNA does not occur. At this age insects have also there is a gradual shrinkage of ribosomal genes. The lack of rDNA is inherited, that is, the offspring has the same mutation in stem cells, and their fathers. The older was a male when he got the offspring, the fewer copies of rDNA was the latter.
It turned out that the cells of the offspring have restored the number of ribosomal genes in 10-day age. This renewal, according to scientists, is necessary to ensure that the stem cells retain their functionality with the change of generations. The same mechanism should exist in humans, experts say.
Video, photo All from Russia.