Photo: Cris Faga / Globallookpress.com
An international group of scientists have discovered a mechanism that triggers the development of obesity and is associated with resistance to leptin (the hormone control weight). About it reported in a press release on MedicalXpress.
The molecules of the leptin released from the cells of white adipose tissue during a meal. Via the bloodstream the hormone enters the brain in the hypothalamus, where it interacts with proteins on the surface of neurons. Shown that people with excess weight in the blood has a lot of leptin, but this does not affect their satiety. This condition is called resistant to the leptin and it is believed that it is responsible for the development of obesity.
The researchers found that mice that receive a large amount of fat with food is formed of an enzyme called matrix metalloproteinase 2 (MMP-2) inhibits the binding of leptin to receptors of nerve cells in the hypothalamus. MMP-2 causes damage to receptors. In turn, this blocks the signals from the neurons involved in the formation of the feeling of satiety.
Scientists were able to inhibit the activity of MMP-2 and show that in this case, leptin begins to contact the neurons that reduces the tendency to overeat. The researchers hope that the results will help to develop an inhibitor of proteases, which would be effective for the human body. However, the presence of such a mechanism in humans remains unclear.
Video, photo All from Russia.