Image: Dr Padman at Monash Micro Imaging
The scientists of the Monash University (Australia) has identified a key process in all human cells, which contributes to aging and development of age-related diseases such as cancer or neurodegenerative disorders. About it reported in a press release on MedicalXpress.
The researchers studied autophagy, in which cells recognize, engulf and destroy defective proteins, fragments of cell membranes, parts of viruses or bacteria. Captured “garbage” is used by the cell to produce the energy and substances necessary for its activity. In the absence of effective autophagy cells have overwhelmed their own waste throughout the body can cause various diseases, including diabetes, muscular dystrophy, Parkinson’s disease and Alzheimer’s.
Recognition and binding of “garbage” occurs via specific protein receptors, after which he is captured by an insulating membrane and sent to the lysosome where it is destroyed. It was believed that the contact of receptors with the bodies that you want to capture, activate membrane. However, scientists have discovered that blocking the receptor from binding to membranes does not stop the process. Instead involve membrane receptors, in order to autophagy proceeded more efficiently. Failures that occur at this stage, are a real cause of disease.
Currently being developed drugs that should regulate the receptors that work quite differently, as experts previously thought. It is necessary to develop new tools, taking into account the discovered mechanism, the scientists conclude.
Video, photo All from Russia.