Image: NIAID / NIH
An international group of scientists found a way to reactivate T cells, which were depleted in the fight against cancer. About it reported in a press release on MedicalXpress.
It is known that one of the reasons because of which a person’s immune system is not able to cope with cancer is that the tumor-infiltrating lymphocytes lose energy when attacking malignant cells. This is due to the fact that the tumor absorbs glucose, depriving T cells of resources. The immune system some time to grapple with the tumor, but then stops doing so, allowing it to grow further.
The researchers found that the cause of the depletion of lymphocytes is the reduction in their number of enolase 1 enzyme, which plays a role in glycolysis, oxidation of glucose. The result is a tenfold decrease in the rate of oxidative phosphorylation, in which energy is stored in the form of ATP molecules. To avoid this, the researchers forced the cells to absorb the pyruvate end product of glycolysis. This has led to the growth of the energy in the lymphocytes and their activation.
Based on the results of the study, the researchers have created a combination drug of inhibitors control points (substances, abolishing immune suppression), which was tested on mice. The animals were observed activation of lymphocytes and tumor growth. In future experiments involving humans.
Video, photo All from Russia.