Identified the main causes of premature death

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Photo: John Kolesidis / Reuters

An international group of scientists from Russia, the UK and the Netherlands have identified genes that contribute to the development of age-related diseases and premature death. About it reported in a press release on EurekAlert!.

The researchers analyzed genetic data and medical history more than 300 thousand patients aged 37-73 years, stored in a database UK Biobank. It turned out that diseases such as cancer, diabetes, chronic obstructive pulmonary disease, stroke, dementia, caused by the mechanisms underlying the aging process. However, the risk of diseases increases exponentially after age 40 and doubles every eight years, which corresponds to the law of Gompertz about the relationship of mortality with age.

Scientists have discovered 12 loci, that is, corresponding to the location of certain genes are sections of DNA that influence the expected duration of healthy life. Three of them HLA-DBQ, LPA and CDKN2B — have been identified in previous studies as associated with longevity. The results of the new work has shown that the first gene determined the risk of developing obstructive lung disease, diabetes, cancer, and dementia. Genetic variants in the vicinity of the tyrosinase gene associated with a probability of premature death and macular degeneration.

The researchers also found five single nucleotide substitutions (SNPs) associated with cancer of the skin, skin color, eyes and hair, tan, freckles, coronary disease, cholesterol and glucose, body mass index and diabetes mellitus of the 2nd type. Many of these characteristics demonstrate a strong correlation with the healthy life expectancy.

Video, photo All from Russia.



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