Scientists at Tokyo University have come to the conclusion that global warming contributes to reduced immunity of animals and humans and make them more vulnerable to various viral infections and other pathogens. Article researchers published in the journal Proceedings of the National Academy of Sciences.
In the experiment, scientists placed healthy female mice in the chamber with cold air (4 degree Celsius), air at room temperature (22 degrees) and hot air (36 degrees). On the eighth day of stay in the chambers the animals were infected with influenza virus strain A/PR8.
Within seven days of being in high temperatures, the rodents ate little and lost 10 percent of initial body weight. In addition, it was found that they significantly decreased the number produced in the lungs of cytotoxic T lymphocytes CD8+ T specific for the virus, as well as the amount of IgG antibodies.
High temperatures prevented the development of proinflammatory molecules cytokines and activation inflammasomes — protein complexes that trigger the inflammatory response. On the seventh day of infection the content of virus in the lungs remained high. Also in mice exposed to hot air, there was an increase in the lungs of autophagy — the process of destruction of unnecessary or damaged components of cells.
In rodents maintained at room temperature, artificial activation of autophagy reduced ability to fight infection. However, injection of glucose and short-chain fatty acids restored the violated because of the high temperature activity of the immune system.
Video, photo All from Russia.