An international group of scientists from Germany, the UK and the USA have discovered a protein complex that prevents the formation of protein aggregates observed in neurodegenerative incurable diseases such as Alzheimer’s disease, Huntington’s chorea and spinocerebellar ataxia. This publication reports Science Daily.
Polypeptide-associated complex (NAC) is a chaperone, that is, its function is to restore the proper structure of proteins and elimination of compounds with a defective structure. Scientists have shown that it recognizes are prone to aggregation of the protein types, including those that contain polyglutamine (PolyQ), and inhibits the formation of plaques associated with damage to nerve tissue.
The researchers analyzed nerve cells in mice, which were reduced level of NAC. It turned out that they were actively formed toxic forms of PolyQ proteins, leading to damage of organelles. Scientists have determined that a key role in preventing the emergence of aggregates plays a binds to the ribosome subunit of the N-βNAC.
Video, photo All from Russia.