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Scientists Medical College named after albert Einstein in the United States found that the number of mutations in somatic cells increases with age. Researchers believe that this process is the key to aging and cancer. About it reported in a press release on MedicalXpress.
Biologists sequenced (determined the nucleotide sequence of the) gene In lymphocytes of people up to the age of 100 years. it appeared that in newborns the average number of mutations reached 463,4, people 27-30 years — 1181,9 mutations, and those who have reached the age 52-75 years 2101,7 mutations. Centenarians have (97-106 years) was observed 3127 mutations. The majority of changes in DNA were unique to one particular cell and appeared randomly throughout the genome.
However, the researchers found that in some parts of the genome the probability of occurrence of mutations was higher than in others. In addition, some changes to the genome was similar in nature to those that occur in tumours. With age also increases the number of nucleotide substitutions in the DNA regulating the activity of genes and open chromatin regions of chromosomes, where the regulatory sequence.
Video, photo All from Russia.