For the first time disclosed a universal program of aging

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An international group of scientists from the United States and Russia established medications that can effectively prolong life in humans. To do this, they identified a universal program of aging, analyzed the activity of genes in normal and long-lived nematodes with increasing age. Article researchers published in Scientific Reports.

The researchers received 60 of the transcriptome (the set of RNA molecules produced by the genes) of the nematode Caenorhabditis elegans all ages, including four of the mutant is long-lived. The average life expectancy last in the 2.2-9.4 times higher than normal. It turned out that with age, changes occur in the concentration of different transcripts called a transcript drift (drift transcriptomic), while these changes have different worms had similar characteristics.

Scientists have suggested that this is due to the existence of the aging process. The main idea was that there should be some kind of one variable characterizing the regulatory network of genes, and thus it should determine the biological age.

Analysis of the transcriptome showed that the contribution to the biological age 71 brings the gene. This allowed the researchers to determine chronological age biological age of each nematode regardless of its lifespan. In other words, the researchers determined a General measure of the “criticality” the regulatory network of genes. Thus, aging is a consequence of internal instability, lack of control over the activity of genes. This helps to determine what interventions will significantly increase life expectancy.

The scientists compared the transcript pattern of aging in long-lived and normal forms with diagrams of the changes in transcripts when exposed to certain drugs. This approach gave the list of medicines whose action causes changes in human RNAS, the opposite process of aging. Among them, the most promising was the anisomycin, alsterpavillon, azacitidine and Metamizole.

It is known that certain mutations in the genes greatly increase the life of worms, for example, changing the gene age-1 extends life by almost 10 times. However, locking of the respective RNA transcripts, especially begun at a later age, does not lead to the desired effect. This is because mutations may change the genetic “tuning” of the whole organism during development and aging of mutant forms may be different and it is not easy to achieve with the therapeutic approach.

Video, photo All from Russia.



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