Photo: Monash University
Scientists at the Monash University in Australia has identified factors affecting aging of the immune system. It turned out that the decreased production of specific proteins disrupts the function of the stem cell composition of the thymus, the organ in which the maturation and immunological education of lymphocytes. About it reported in a press release on MedicalXpress.
It is shown that the thymus (thymus gland) is most productive after birth and produces all the variety of lymphocytes, but with age becomes less effective. In the elderly dysfunction of this organ leads to a less efficient immune system, increasing susceptibility to infections and cancer development.
It turned out that the deterioration of the thymus are the factors influencing the growth and differentiation of epithelial stem cells. The researchers found that old people decreased production of bone morphogenetic protein BMP4 and protein complex activin. As a result, in the thymus there is a loss of Mature epithelial cells and reduced production of T-lymphocytes.
According to the researchers, the results will help to develop strategies for temporary improvement of the condition of the thymus and restoration of the diversity of T-cells.
Video, photo All from Russia.