Photo: Sebastian Kahnert / DPA / Globallookpress.com
Scientists at Yale University (USA) found that the structure of the tissues, called the extracellular matrix and involved in mechanical support for cells, can play an important role in the progression of the threat of heart disease, including hypertrophic cardiomyopathy. Under this condition, a healthy-looking person could drop dead from physical exertion. About it reported in a press release on MedicalXpress.
The researchers found that the extracellular matrix (ECM) participates in the development of hypertrophic cardiomyopathy — a genetic disorder in which there is a thickening of the heart muscle. The researchers studied which form the ECM of connective tissue of a pig was the animal model of cardiomyopathy. Defective heart cells were removed from tissue and replaced with a healthy heart muscle cells. However, it turned out that the latter became worse to relax and slowly declined.
It was found that cardiac tissue on the affected matrix required double the effort to stretch to the same length as the fabric on a healthy matrix. The stiffness of the support structure makes the cells become larger, which explains the overgrowth and thickening of the muscle with cardiomyopathy.
In hypertrophic cardiomyopathy, which is genetic and affects approximately one in 500 people, there is a thickening of the walls of the left and right ventricle. This condition is considered a common cause of death among young athletes, who had no visible symptoms. The older patients dying from congestive heart failure.
Video, photo All from Russia.