Disclosed the reason for and method of controlling the disease Stephen Hawking


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Researchers at Stanford University in the US have discovered a key gene involved in the synthesis Deplete the nerve cells of the substances in side, amyotrophic lateral sclerosis (disease Lou Gehrig’s disease), which suffered theoretical physicist Stephen Hawking. About it reported in a press release on EurekAlert!.

According to the study, the RPS25 gene encodes part of a protein complex, which contributes to the accumulation of toxic compounds. When scientists blocked the gene in yeast, obtained from patients neurons and fruit flies, the levels of pathogenic protein decreased by 50 percent, and life expectancy of the insects increased. In addition, it turned out that disabling reduces RPS25 protein aggregates in the cellular tissues that serve as models of Huntington’s disease and spinocerebellar ataxia.

In lateral amyotrophic sclerosis is the loss of motor neurons. There are many genetic factors in the development of the disease Lou Gehrig, however, one of the most common culprits is a mutation in a single gene, which is expressed in repetition of one of the DNA fragments. Normal genes with the repeats should not encode proteins, but in this case, the synthesized pathogenic protein aggregates that prevent the cells to function properly.

Hawking died 14 March 2018 at the age of 76 years. A scientist most of my life spent in a wheelchair, is widely known as a popularizer of science, in recent years, considerable attention was paid to such problems as global warming, the environment and social inequality.

Video, photo All from Russia.


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