Scientists at Cambridge stem cell Institute in the UK drew the aging of the brain in rats. About it reported in a press release on MedicalXpress.
The researchers studied the Central nervous system of young and old rodents, to determine the effect of increasing the stiffness of the brain on the function of progenitor cells of oligodendrocytes (OPC). Oligodendrocytes, a kind of glial cells, insulate long processes (axons) of neurons, creating the myelin sheath, and increasing the speed of the pulses. It is known that this shell is damaged in multiple sclerosis.
In the experiment, the biologists transplanted OPC old rats into the brain of young animals. It turned out that the cells were returned to the young phenotype. Scientists have also created a variety of materials that simulate the young and the old, more rigorous brain. OPC was removed from the protein Piezo1, which signals the cell is the medium soft or hard. In the absence of protein cells even tough material is “felt” soft and restored the old ability to regenerate.
Scientists hope that their findings will help to develop new approaches to the treatment of patients with multiple sclerosis.
Multiple sclerosis is a chronic autoimmune disease in which there is a violation of the myelin sheath of nerve fibers in the brain and spinal cord, affects various parts of the nervous system. Effective treatment of the disease does not yet exist, and the average life expectancy of patients by 5-10 years less than healthy people.
Video, photo All from Russia.