Scientists at the University of Kentucky have identified a new mechanism of metastasis of colorectal cancer, which can become a target for new drugs. About it reported in a press release on MedicalXpress.
Researchers have identified two new splicing variant of the NRP1 gene, which encodes a protein of neuropilin-1 (NRP1). When splicing is the cutting out of certain nucleotide fragments (its introns are) from the mRNA molecule (mRNA), which thus passes into the Mature form. Errors in this process lead to incorrect nucleotide sequences of mRNA and, consequently, to defective forms of the protein. In the case of NRP1 both are defective and contribute to the development of intractable forms of cancer.
It turned out that a new form of the transmembrane protein NRP1 form complexes with specific compounds and provide strong signals for the activation of the metabolic pathway FAK/p130Cas. Overall, all this helps the migration, invasion and metastasis of colorectal cancer cells. These cells are also resistant to drugs that inhibit the tyrosine kinase activity of MET.
The results will help develop therapeutics against metastasis, in which complexes with neuropilin-1 can be effectively blocked.
Video, photo All from Russia.