Frame: video Yankner lab / Harvard Medical School
Scientists at Harvard medical school in the US found that excess neural activity in the brain, which is associated with dementia and epilepsy, plays a role in aging and contributes to the short duration of human life. About it reported in a press release on EurekAlert!.
The researchers analyzed genes in the brain tissues of people who died at the age of 60 to 100 years. It turned out that people who lived to a ripe old age, demonstrated lower activity of genes associated with nervous excitement, than those who died at the age of 60-80 years. DNA activity was determined by the number of transcripts — RNA molecules synthesized during gene expression.
Additional experiments on nematodes and genetically modified mice, as well as analysis of brain tissues of centenarians demonstrated a causal relationship between changes in nervous excitement and life expectancy. Thus the key role played by a protein REST, which suppresses excessive activity of neurons. Blocking this protein increases the risk of early death.
Video, photo All from Russia.