Found a way to prevent a deadly attack

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Scientists at Bristol University have found a way to prevent sudden death from heart failure. About it reported in a press release on MedicalXress.

The researchers found that the impact on the membrane potential during the formation of the wave excitation to prevent a potentially fatal disruption of the heart and increase the force of contractions in failure.

The immediate cause of arrhythmia are early postdeposition (EAD). They arise during the repolarization of the membrane due to reactivation of ion currents. Currents of potassium ions in this case is not able to maintain the correct repolarization. Waves of calcium ions inside cells are also involved in the occurrence of EAD, however, it was not clear what they can be caused.

Was that a violation of a simultaneous release of calcium in the early stages of the action potential contributes to the appearance of the late “sparks” of calcium, that is, small events releasing ions, capable of spreading and forming waves. The latter, in turn, produces sodium-calcium current, which counteracts the repolarization. The recovery of repolarization and improves synchrony of calcium release and reduce the rate of “sparks”. It also reduces the risk of sudden death due to heart failure.

Action potential — a wave of excitation that travels along the cell membrane. It has several phases, including a slow depolarization of the membrane (prespic), peak potential consisting of depolarization and repolarization, and trace capabilities.

Video, photo All from Russia.

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