Photo: Tel Aviv University
Scientists at Stanford University in USA have developed a new noninvasive method of treating malignant neoplasms by using low-frequency ultrasound. This method allows you to destroy up to 80 percent of cancer cells. The study is published in the journal Proceedings of the National Academy of Sciences.
In the experiment, the scientists created a gas filled microbubbles, whose diameter is small enough to easily pass through the blood vessels to the tumor. They were mixed with plasmids (circular DNA molecules), carrying the gene of interferon IFN-β, after which they injected mice with breast tumor. Ultrasound is a frequency of 250 kHz were forced microbubbles attached to the tumor to oscillate and explode, creating a pressure of 500 kPa and destroying the membrane of cancer cells. So it was destroyed 80 percent of the cells and through the pores inside 20 percent of the remaining easily penetrated plasmids, which began to produce interferon, which is a signal molecule for initiation of an immune response.
It is shown that the interferon was synthesized in an amount which is several times higher than the value reached in previous studies. This allowed to significantly inhibit the tumor growth of the remaining cancer cells. Despite the fact that scientists directly impacts on one part of the tumor, the immune response developed in other areas of the cancerous tissues.
In the future, the researchers plan to test the method in the fight against brain tumors and neurodegenerative diseases such as Parkinson’s or Alzheimer’s.
Video, photo All from Russia.